R-253 Disrupts Microtubule Networks in Multiple Tumor Cell Lines
نویسندگان
چکیده
منابع مشابه
R-253 disrupts microtubule networks in multiple tumor cell lines.
PURPOSE The design and development of synthetic small molecules to disrupt microtubule dynamics is an attractive therapeutic strategy for anticancer drug discovery research. Loss of clinical efficacy of many useful drugs due to drug resistance in tumor cells seems to be a major hurdle in this endeavor. Thus, a search for new chemical entities that bind tubulin, but neither are a substrate of ef...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2006
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-06-0168